Professor Mark Kotter, University of Cambridge
In MS, the immune system mistakenly attacks and damages myelin: the protective coating around nerve fibres. This damage can result in nerve cell death, leading to the accumulation of disability seen in MS. There is an urgent need for therapies that focus on myelin repair and slow or stop the progression of disability.
Through the collaboration of the Kotter and Rotshenker laboratories, this project aims to identify novel ways of promoting myelin repair and preventing nerve cell death. They focus on removing the debris built up during myelin damage, and stimulating remyelination of exposed nerve fibres.
This research has the potential to address the currently unmet need for regenerative treatments that prevent the gradual worsening of disability seen in MS.